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Research articles

ScienceAsia 48 (2022):ID 657-663 |doi: 10.2306/scienceasia1513-1874.2022.095

Down-regulation of RNF146 promotes gastric cancer cell apoptosis and inhibits cell migration via Wnt/β-catenin signaling pathway

Rousidan Tuerdi, Peng Li*, Yibula yin Xilifu, Ailixier

ABSTRACT:     Gastric cancer (GC) is one of the high mortality rate cancers in the world, and seeking more effective treatment methods has always been one of the urgent clinical problems to be solved. Therefore, a thorough understanding of GC pathogenesis is necessary. The E3 ubiquitin ligase ring finger protein 146 (RNF146) has been implicated as the important factor in tumor evolution. However, its role in GC has not been well investigated. In the present study, our results first showed that RNF146 was up-regulated in both GC tissues and GC cell lines. In addition, RNF146 knockdown induced cell apoptosis and inhibited cell migration and invasion in HGC27 cells. However, these phenomena could be reversed by RNF146 over-expression. Furthermore, our results demonstrated that RNF146 possessed oncogenic role through down-regulating the expression of Axin1 to activate ?-catenin signaling pathway. Collectively, these results indicated that RNF146 might be regarded as a carcinogen in human GC and representing as a promising and valuable therapeutic target for the GC treatment.

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a Department of General Surgery, Urumqi Friendship Hospital, Urumqi, Xinjiang 830049 Chin

* Corresponding author, E-mail: pengli9734@163.com

Received 2 Nov 2021, Accepted 1 Mar 2022