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Research articles

ScienceAsia 48 (2022):ID 650-656 |doi: 10.2306/scienceasia1513-1874.2022.094

Association of placental toll-like receptor 4 and fatty acid transport protein expression with neonatal weight

Jianli Zhou, Nannan Zhao, Jinling Yuan, Ying Liu, Jun Xing*

ABSTRACT:     Fetal macrosomia is associated with several maternal and fetal complications. Toll-like receptors (TLRs) and fatty acid transport proteins (FATPs) are related with fetal growth and development. However, the association of the levels of TLR and FATP expression in placenta with neonatal weight is not known. Thus, we sought to evaluate the effect of blood lipid, TLRs, and FATPs on neonatal weight. According to birth weight, specimens were divided into four groups: low (? 3000 g), middle (3000 g < and ? 3500 g), high (3500 g < and ? 4000 g), and macrosomia (> 4000 g) groups. The blood lipid levels, TLR4 expression level in the umbilical vein serum, and TLR4, FATP2, and FATP4 mRNA and protein expression levels in placental tissue were measured. The risk factors of fetal macrosomia, which had significant difference among the low, middle, high, and macrosomia groups, included maternal blood triglyceride (TG) and high-density lipoprotein (HDL), cord blood TG and HDL, placental weight, TLR4, FATP2, and FATP4. Multivariate logistic regression analysis indicated that the risk of fetal macrosomia was positively correlated with the TLR4 (odds ratio = 3.053, p = 0.018), FATP2 (odds ratio = 4.824, p = 0.001), and FATP4 (odds ratio = 3.201, p = 0.014). Among them, FATP2 had the most significant effect on neonatal weight. Therefore, neonatal weight could be regulated by the FATP2 expression level, which could reduce the incidence of maternal and fetal complications caused by abnormal weight.

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a Department of Obstetrics and Gynecology, North China University of Science and Technology Affiliated Hospital, Hebei 063000 China

* Corresponding author, E-mail: mdxj2012@126.com

Received 3 Nov 2021, Accepted 22 Apr 2022