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Volume 44 Number 2 Volume 44 Number 3 Volume 44 Number 4

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Research articles

ScienceAsia 44 (2018): 170-178 |doi: 10.2306/scienceasia1513-1874.2018.44.170

Phytochemicals, cytotoxicity, and genotoxicity of three Artocarpus species reveal arbutin in A.˙lacucha

Kowit˙Noikotra,b, Arunrat˙Chaveeracha,c,*, Runglawan˙Sudmoona,d, Tawatchai˙Taneea,e, Natcha˙Patarapadungkita,f

ABSTRACT:     Leaves of three Artocarpus species were hexane and ethanol extracted and chemically analysed. Cytotoxicity and genotoxicity tests were performed on peripheral blood mononuclear cells. The main phytochemical in the hexane extracts was (Z)-9-octadecenamide (oleamide). The ethanol extracts showed 21% 9,19-cyclolanost-24-en-3-ol in A.˙altilis, 19% n-hexadecanoic acid in A.˙heterophyllus, and 21% arbutin in A.˙lacucha. The hexane extract of A.˙altilis gave an IC50 of 0.00035˙mg/ml but no IC50 values for A.˙heterophyllus and A.˙lacucha extracts. Ethanol extracts of A.˙altilis and A.˙lacucha had IC50 values of 0.868 and 0.218˙mg/ml, respectively, but none for A.˙heterophyllus. All the hexane extracts showed non-significant DNA damage, while all the ethanol extracts significantly induced DNA damage (p<0.05). A.˙lacucha leaf is newly reported as an alternative source of arbutin.

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a Genetics˙and˙Environmental˙Toxicology˙Research˙Group, Khon˙Kaen˙University, Khon˙Kaen˙40002˙Thailand
b Department˙of˙Biology, Faculty˙of˙Science, Ramkhamhaeng˙University, Bangkok˙10240˙Thailand
c Department˙of˙Biology, Faculty˙of˙Science, Khon˙Kaen˙University, Khon˙Kaen˙40002˙Thailand
d Faculty˙of˙Law, Khon˙Kaen˙University, Khon˙Kaen˙40002˙Thailand
e Faculty˙of˙Environment˙and˙Resource˙Studies, Mahasarakham˙University, Maha˙Sarakham˙44150˙Thailand
f Department˙of˙Pathology, Faculty˙of˙Medicine, Khon˙Kaen˙University, Khon˙Kaen˙40002˙Thailand

* Corresponding author, E-mail: raccha@kku.ac.th

Received 22 Aug 2017, Accepted 7 Aug 2018