Research articles
ScienceAsia 44 (2018): 170-178 |doi:
10.2306/scienceasia1513-1874.2018.44.170
Phytochemicals, cytotoxicity, and genotoxicity of three Artocarpus species reveal arbutin in A.ÿlacucha
KowitÿNoikotra,b, ArunratÿChaveeracha,c,*, RunglawanÿSudmoona,d, TawatchaiÿTaneea,e, NatchaÿPatarapadungkita,f
ABSTRACT: Leaves of three Artocarpus species were hexane and ethanol extracted and chemically analysed. Cytotoxicity and genotoxicity tests were performed on peripheral blood mononuclear cells. The main phytochemical in the hexane extracts was (Z)-9-octadecenamide (oleamide). The ethanol extracts showed 21% 9,19-cyclolanost-24-en-3-ol in A.ÿaltilis, 19% n-hexadecanoic acid in A.ÿheterophyllus, and 21% arbutin in A.ÿlacucha. The hexane extract of A.ÿaltilis gave an IC50 of 0.00035ÿmg/ml but no IC50 values for A.ÿheterophyllus and A.ÿlacucha extracts. Ethanol extracts of A.ÿaltilis and A.ÿlacucha had IC50 values of 0.868 and 0.218ÿmg/ml, respectively, but none for A.ÿheterophyllus. All the hexane extracts showed non-significant DNA damage, while all the ethanol extracts significantly induced DNA damage (p<0.05). A.ÿlacucha leaf is newly reported as an alternative source of arbutin.
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| a |
GeneticsÿandÿEnvironmentalÿToxicologyÿResearchÿGroup, KhonÿKaenÿUniversity, KhonÿKaenÿ40002ÿThailand |
| b |
DepartmentÿofÿBiology, FacultyÿofÿScience, RamkhamhaengÿUniversity, Bangkokÿ10240ÿThailand |
| c |
DepartmentÿofÿBiology, FacultyÿofÿScience, KhonÿKaenÿUniversity, KhonÿKaenÿ40002ÿThailand |
| d |
FacultyÿofÿLaw, KhonÿKaenÿUniversity, KhonÿKaenÿ40002ÿThailand |
| e |
FacultyÿofÿEnvironmentÿandÿResourceÿStudies, MahasarakhamÿUniversity, MahaÿSarakhamÿ44150ÿThailand |
| f |
DepartmentÿofÿPathology, FacultyÿofÿMedicine, KhonÿKaenÿUniversity, KhonÿKaenÿ40002ÿThailand |
* Corresponding author, E-mail: raccha@kku.ac.th
Received 22 Aug 2017, Accepted 7 Aug 2018
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