| Home  | About ScienceAsia  | Publication charge  | Advertise with us  | Subscription for printed version  | Contact us  
Editorial Board
Journal Policy
Instructions for Authors
Online submission
Author Login
Reviewer Login
Volume 49 Number 4
Volume 49 Number 3
Volume 49 Number 2
Volume 49 Number 1
Volume 48 Number 6
Volume 48 Number 5
Earlier issues
Volume 41 Number 5 Volume 41 Number 6 Volume 42 Number 1

previous article next article

Research articles

ScienceAsia 41 (2015): 392-399 |doi: 10.2306/scienceasia1513-1874.2015.41.392

Anti-inflammatory activity of a Vernonia cinerea methanolic extract in vitro

Aurasorn Saraphanchotiwitthayaa,b,*, Pattana Sripalakitb,c

ABSTRACT:     Vernonia cinerea Less. (Asteraceae) is a herbaceous plant commonly found in SE Asia. Different parts of V. cinerea have been used in various folklore medicine applications, including reducing inflammation and detoxification. This study investigates the effects of V. cinerea methanolic extract on the mouse immune system in vitro. Cytokine detection of ConA-stimulated splenocytes using ELISA, mitogen-induced splenocyte proliferation, and phagocytic activity were assayed. The results show that the extract shifted the Th1/Th2 balance towards a Th2 type response. Additionally, Th1- and Th2-related cytokine production correlated with lymphocyte proliferation by selective activation of T-cells into Th2-cells and suppression of Th1-cell proliferation. Our results confirmed the traditional applications of V. cinerea on immune-related remedies and anti-inflammation, suggesting a potential therapeutic application of this plant in the treatment of diseases associated with soma carisoprodol cytokine production and inflammation.

Download PDF

44 Downloads 1294 Views

a Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand
b Pharmaceutical Biotechnology Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand
c Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand

* Corresponding author, E-mail: aurasorns@nu.ac.th

Received 6 Aug 2014, Accepted 2 Nov 2015