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Research articles

ScienceAsia 40 (2014): 285-289 |doi: 10.2306/scienceasia1513-1874.2014.40.285

Systemic low-grade inflammation in siblings of type 2 diabetic patients

Yousef Rasmia,b,*, Mohammad Golizadehc, Neda Valizadehd, Masoud Saleh-Moghaddamc

ABSTRACT:     Chronic low-grade inflammation is involved in the development of diabetes mellitus type 2 (DMT2). Because of genetic inheritance, first-degree relatives of DMT2 patients are at increased risk of developing this metabolic disorder. We aimed to investigate the association of inflammation in the development of DMT2 in siblings of DMT2 patients. Twenty seven DMT2 patients and 27 healthy individuals without a family history of DMT2 were enrolled. Plasma levels of the high sensitive C-reactive protein (hs-CRP), tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), and fibrinogen (FIB), as inflammatory factors were assessed in all individuals. Levels of hs-CRP, TNF-α, IL-6, and FIB were significantly higher in DMT2 patients than in their siblings. Furthermore, all marker levels were found to be significantly higher in the siblings group than in healthy controls. Siblings of DMT2 patients are then at higher risk for DMT2 than healthy controls. Systemic inflammatory abnormalities may play an important role in the development of diabetes mellitus in siblings via endothelial dysfunction.

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a Cellular and Molecular Research Centre, Urmia University of Medical Sciences, Urmia, Iran
b Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
c Department of Biology, Faculty of Sciences, Mashahd Payame Noor University, Mashhad, Iran
d Department of Endocrinology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

* Corresponding author, E-mail: rasmiy@umsu.ac.ir

Received 1 Sep 2012, Accepted 19 Mar 2014