Research articles
ScienceAsia 50 (2024):ID 2024056 1-8 |doi:
10.2306/scienceasia1513-1874.2024.056
Formulation of chewable nutraceuticals prepared from
banana fruit pulp and hemp seed oil
Chatnarong Putthonga, Prapapan Temkitthawonb, Preeyawass Phimnuana, Jarupa Viyocha,*, Kongaphisith Tongpoolsomjitc,*
ABSTRACT: This study aimed to develop a chewable tablet nutraceutical by combining dried banana powder and coldpressed hemp seed oil as two major raw materials. Powdered bananas (Musa AA group) and hemp seed oil (Cannabis
sativa L.) were obtained by grinding their respective lyophilized fresh fruit pulps. The chewable nutraceutical formula
is composed of 70% w/w banana powder and 5% w/w hemp seed oil. The RP-HPLC analysis revealed that the banana
powder contained 1,076.9?147.1 ?g of ?-carotene per gram. Oil extracted from hemp seeds contained 56.23% w/w
linoleic acid (18:2n6) and 15.19% w/w alpha-linolenic acid (18:3n3) (omega 6 to omega 3; 4:1). In addition, the
developed HPLC method showed that the oil contained cannabidiol (CBD) at a level of 21.85?0.91?10?4% w/w, with
no traces of tetrahydrocannabinol (THC). The hardness of the nutraceutical was in the range of 45?5 N with the
thickness in the range of 4?0.3 mm. It contained 1,080.0?55.2 ?g of ?-carotene per 1,200 mg tablet. The remaining
content of ?-carotene after one month of storage at temperatures of 5?3 ?C and 32?3 ?C with relative humidity of
75?5% was 98.4% w/w and 90.5% w/w, respectively. Tablets must be protected against high heat and moisture to
prevent ?-carotene oxidation. More study is required to establish the tablet effectiveness in the container under the
label parameters such as dry air at room temperature for 1?2 years.
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a |
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for
Innovation in Chemistry, Naresuan University, Phitsanulok 65000 Thailand |
b |
Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences,
Naresuan University, Phitsanulok 65000 Thailand |
c |
Department of Industrial Chemistry, Faculty of Applied Science, King Mongkut?s University of Technology
North Bangkok, Bangkok 10800 Thailand |
* Corresponding author, E-mail: jarupav@nu.ac.th, kongaphisith.t@sci.kmutnb.ac.th
Received 21 Sep 2023, Accepted 24 Apr 2024
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