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ScienceAsia (): 317-321 |doi: 10.2306/scienceasia1513-1874...317


Antidiabetic activity of leaf and callus extracts of Aegle marmelos in rabbit


Sevugan Arumugama, Subramanian Kavimanib, Balamuthu Kadalmanic, Abdul Bakrudeen Ali Ahmedd, Mohammed Abdulkadar Akbarshac, Mandali Venkateswara Raod,*

 
ABSTRACT:     Aegle marmelos (the bael tree) is a popular medicinal plant in the Ayurveda and Siddha systems of medicine and folk medicines used to treat diabetes. The present study was undertaken to find the extent to which calluses obtained from leaf explant of A. marmelos has a potential for application in diabetes management compared to the ordinary plant material. Treatment using extracts from both leaf and callus produced significant decreases in blood sugar level in streptozotozin diabetic rabbits. Among the various extracts, the methanol extracts of the leaf and callus brought about the maximum anti-diabetic effect. The study revealed that the in vitro callus culture of A. marmelos has as much potential in diabetes management as the original leaf extract.

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a National Taiwan University, Taipei 106, Taiwan
b Mother Theresa Institute of Health Science, Pondicherry, India
c Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India
d Department of Plant Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India

* Corresponding author, E-mail: mvrao_456@yahoo.co.in

Received 1 Nov 2007, Accepted 4 Jul 2008