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Research articles

ScienceAsia 50 (2024):ID 2024064 1-7 |doi: 10.2306/scienceasia1513-1874.2024.064


Evaluation of the antioxidant and anti-leukaemic effects of Andrographis paniculata methanol extract


Hoang Thanh Chia, Vo Ngoc Tramb, Nguyen Trung Quanb, Bui Thi Kim Lya,*

 
ABSTRACT:     Andrographis paniculata is widely used in traditional medicine for treating human diseases. Although there are many scientific reports on this plant?s bio-effects, the lack of leukaemia inhibition impact still remains. In this study, A. paniculata methanol extract (MeAP) was investigated for its antioxidant capacity by DPPH and FRAP assays and for the anti-leukemic effect. The results showed that MeAP could scavenge the DPPH and donate an electron in the FRAP reaction. The cytotoxicity of MeAP was clarified as being strongly selective on Tel-TrkC fusion protein-associated Acute Myeloid Leukaemia (AML) cells with the IC50 = 8.48?0.21 ?g/ml in a dependent manner of dose, time, and cell-density. Moreover, MeAP also inhibited Tel-TrkC phosphorylation.

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a Department of Medicine and Pharmacy, Thu Dau Mot University, Thu Dau Mot, Binh Duong 820000 Vietnam
b Department of Biology and Biotechnology, VNU University of Science, Vietnam National University, Ho Chi Minh City 72711 Vietnam

* Corresponding author, E-mail: lybtk@tdmu.edu.vn

Received 25 Apr 2023, Accepted 1 May 2024