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Research articles

ScienceAsia 49 (2023):ID 15-21 |doi: 10.2306/scienceasia1513-1874.2023.127


Antioxidant activity, α-glucosidase inhibition, and phytochemical profiling of Belosynapsis ciliata (Blume) R.S.Rao extracts


Supawadee Seubsasanaa,*, Bhanuz Dechayontb, Weerachai Pipatrattanasereec, Nipapan Malisornb

 
ABSTRACT:     Diabetes mellitus (DM) is a chronic metabolic disorder associated with persistent hyperglycemia. Globally, the number of people with DM has quadrupled in the past three decades, and type 2 diabetes mellitus (T2DM) accounts for around 90% of all cases of diabetes. The role of oxidative stress is well established in T2DM pathogenesis. The synthetic drugs for T2DM are associated with serious side effects. Antioxidant and ?-glucosidase inhibitory actions of phytochemicals from various plant species are considered an alternative to the synthetic drugs for T2DM management. This study aimed to evaluate the antioxidant activity, ?-glucosidase inhibition, and phytochemical profiling of Belosynapsis ciliata. The total phenolic and flavonoid contents, antioxidant activity of 1,1-diphenyl-2- picrylhydrazyl (DPPH) free radical, 2,20 -azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) free radical, and nitric oxide (NO) radical, and ?-glucosidase inhibition of B. ciliata extracts were determined spectrophotometrically. The ethyl acetate extract form B. ciliata had highly potent scavenging activities for DPPH (EC50; 80.02?4.34 ?g/ml) and ABTS (EC50; 97.07?1.52 ?g/ml). Meanwhile, the dichloromethane extract possessed a good scavenging of NO (IC50; 121.65?3.48 ?g/ml) and had the highest ?-glucosidase inhibitory activity (IC50; 33.28?1.36 ?g/ml). This study demonstrated the promising antioxidant activities, and ?-glucosidase inhibitory action of B. ciliata was probably due to the presence of phenolic and flavonoid contents. The finding provided us with the leads to proceed with the development of medicinal plant having antidiabetic attributes.

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a Faculty of Pharmacy, Thammasat University, Pathum Thani 12121 Thailand
b Faculty of Medicine, Thammasat University, Pathum Thani 12121 Thailand
c Faculty of Medicine, Thammasat University, Pathum Thani 12121 Thailand

* Corresponding author, E-mail: supasn@tu.ac.th

Received 20 Mar 2022, Accepted 10 Jul 2022