Indobet11
   | Home  | About ScienceAsia  | Publication charge  | Advertise with us  | Subscription for printed version  | Contact us  
Editorial Board
Journal Policy
Instructions for Authors
Online submission
Author Login
Reviewer Login
Volume 50 Number 2
Volume 50 Number 1
Volume 49 Number 6
Volume 49 Number 5
Volume 49S Number 1
Volume 49 Number 4
Earlier issues
https://nagaempire7.xyz/ https://empire88t.com/ https://botak-empire5.com/ https://uncleempire19.xyz/ https://indobet11j.com/ https://mukapoker1.lol/ https://mukacasinoc.com/ https://138.197.6.28 https://138.68.168.98 https://152.42.182.182/ https://planetaryconquest.com/ https://internationalpeaceday.com/ https://weidenfeldlaw.com/ https://notariamc.com/ https://inetskate.com/ https://newdatingway.com/ https://korem083.tniad.mil.id/shop/slot-100-perak/ https://korem083.tniad.mil.id/product/slot-qris/ https://korem083.tniad.mil.id/store/bet-200-perak/ https://abkpmi.ac.id/wp-content/uploads/products/slot-qris-10k/
https://www.arabiaphone.com/ https://www.benchmarcsystems.com/ https://www.dndock.com/ https://www.virtuallytheoffice.com/ https://www.mikechomes.com/ https://www.studioelpizo.com/ https://www.musicrebellion.com/ https://www.patmcgann.com/ https://www.hotel-gufler.com/ https://www.aegeaneating.com/ https://www.peterclementbooks.com/ https://www.mahshidabbasi.com/ https://www.elizabethtoop.com/ https://www.stonedeadforever.com/ https://www.longislandsites.com/ https://www.stevenmaloff.com/ https://www.viananaturalhealing.com/ https://www.dascomputers.com/ https://www.systemf3.com/ https://www.visitguanacaste.com/ https://www.independentnepa.com/ https://www.theobooks.org/ https://www.charlieshd.com/ https://www.robertcatkinson.com/ https://www.lechevart.com/ https://www.conkerco.com/ https://www.postgal.com/ https://www.drharoldlong.com/ https://www.blackmenvent.com/ https://www.paranormalresearchonline.com/ http://www.joshkrischer.com/ https://www.riccmho.org/ https://www.iflorabella.com/ https://www.marcellatracco.com/ https://www.juliehutchinson.com/ https://www.fiestadocumentary.com/ https://prakerja.cybersacademy.id/uk/sgacor https://jurnal-fastek.ikopin.ac.id/styles/ http://rodaberita.id/wp-content/botakempire/ https://rodaberita.id/wp-content/empire88/ https://rodaberita.id/wp-content/uncleempire/ https://univ.ikopin.ac.id/wp-content/uncleempire/ https://univ.ikopin.ac.id/wp-content/indobet11/ https://univ.ikopin.ac.id/wp-content/empire88/ https://univ.ikopin.ac.id/wp-content/botak-empire/ https://rodaberita.id/wp-content/indobet11 Botak Empire
Maxwin Botak Empire
Botak Empire Scatter
Daftar Botak Empire
Botak Empire Rekomendasi
Botak Empire Menang
Botak Empire Akun Pro
Scatter Botak Empire
Botak Empire Deposit Receh
Empire88 Slot 4D
Botak Empire Alternatif
https://sakairesources1.ug.edu.gh/uncle-empire https://glodokplaza.com/wp-content/uploads/botak-empire/ https://glodokplaza.com/wp-content/uploads/indobet11/ https://ff.universitasypib.ac.id/wp-content/theme/botak-empire/ https://elearn.nli.gov.mn/naga-empire/ https://dkonveksi.com/ https://elearn.nli.gov.mn/uncle-empire/ https://expressshoerepairnyc.com/wp-content/botak-empire/ https://www.shidokan.org.uk/naga-empire/ https://nagaempire-naga.tumblr.com/ https://ies.edu.vn/wp-content/uncle-empire/ https://glodokplaza.com/wp-content/uncle-empire https://golfdebeaune.com/uncle-empire
Volume  Number 

previous article next article

Research articles

ScienceAsia 49 (2023):ID 38-42 |doi: 10.2306/scienceasia1513-1874.2023.117


Imide cantharidin derivatives: Synthesis and HBV-DNA inhibitory properties


Chun Bin Tana,*, Ya Jing Xinga, Xing Fang Qiaoa,*, Bao Min Fana,b, Xiao-Ling Liua, Yao Bo Zenga,*

 
ABSTRACT:     Cantharidin and its analogs are potent serine/threonine protein phosphatase inhibitors with rare reports on inhibiting expression of Hepatitis B virus (HBV) DNA. Five imide cantharidin derivatives were synthesized, and their properties were studied. The inhibition efficiency was determined, and preliminary studies on the structure-activity relationships were conducted. The results indicated that the compounds characterized by low Log P values and the cantharidin moieties containing nitrogen exhibited low cytotoxicity and helped inhibit the expression of HBV DNA. Compound 2 and the non-cytotoxic compound 3 significantly inhibited the expression of HBV DNA. The IC50 values recorded for both compounds were 2.0?1.2 and 19.2?2.0 nM, respectively.

Download PDF

83 Downloads 1290 Views


a Chongqing Academy of Chinese Materia Mediea, Chongqing 400065 China
b School of Chemistry and Environment, Yunnan Minzu University, Kunming 650503 China

* Corresponding author, E-mail: tcb204@163.com, cqszyy2022@163.com, c0230231111@163.com

Received 11 Feb 2022, Accepted 10 Jun 2022