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Research articles

ScienceAsia 49 (2023):ID 70-76 |doi: 10.2306/scienceasia1513-1874.2023.134


H2O2 suppresses ROS elimination and osteogenesis by inhibiting MT2 expression


Qionghua Yaoa, Jiafu Lina, Shengwang Weib,*

 
ABSTRACT:     Hydrogen peroxide (H2O2 ) can damage the activity of osteoblasts, thus inhibiting the osteogenesis. Metallothionein (MT) is a scavenger of reactive oxygen species (ROS), which can promote the osteogenesis. Our transcriptomic results showed that H2O2 decreased the mRNA expression of MT2 in osteoblasts. This study aims to explore the regulatory effect of MT2 gene on the osteogenesis under oxidative stress. In this study, we explored the effect of MT2 on ROS production in osteoblasts by using gene overexpression or silencing. Then, the role of H2O2 on MT2 expression in osteoblasts was further observed. Ultimately, the effect of MT2 overexpression on osteogenic capacity under H2O2 treatment was investigated. Our results showed that MT2 overexpression reduced ROS production in osteoblasts, while MT2 silencing was contrary. Moreover, MT2 levels in osteoblasts decreased under H2O2 intervention. Importantly, MT2 overexpression reversed H2O2 -inhibited osteoblastic number and activity. In conclusion, this study indicated that H2O2 can inhibit ROS scavenging by downregulating MT2 expression, whereby inhibiting the osteogenesis.

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a Department of Medical College, Fujian Health College, Fuzhou 350101, Fujian China
b Department of Orthopaedics, Liuzhou Workers Hospital, Liuzhou 545005, Guangxi China

* Corresponding author, E-mail: wswworkers@163.com

Received 2 Sep 2021, Accepted 4 Jun 2022