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Research articles

ScienceAsia 48 (2022):ID 429-433 |doi: 10.2306/scienceasia1513-1874.2022.059

Cytotoxic compounds from Goniothalamus repevensis Pierre ex Finet & Gagnep

Waraporn Chanakula,*, Vichai Reutrakulb, Chutima Kuhakarnb, Samreang Bunteangb, Pawinee Piyachaturawatc, Kanoknetr Suksenc, Sakchai Hongthongd, Sariyarach Thanasansurapongb, Narong Nuntasaene

ABSTRACT:     Phytochemical investigation of the methanol extract of the leaves and twigs of Goniothalamus repevensis led to the isolation of five known compounds including two styryl lactones; (?)-goniodiol-7-monoacetate (1) and (?)-goniodiol diacetate (2) as well as three aristolactam alkaloids; piperolactam C (3), aristolactam A III (4), and aristolactam B III (5). The structure determination was established by various spectroscopic methods and by comparison with the literature data. Cytotoxic activity against a panel of mammalian cancerous cell lines of compounds 1?4 was investigated. Piperolactam C (3) was found to be active in all tested cell lines with IC50 values in the range of 3.30?64.6 ?M. (?)-Goniodiol-7-monoacetate (1) exhibited cytotoxic activity only against ASK cells with IC50 value of 10.28 ?M. Having been isolated as a major component, compound 1 can be considered chemotaxonomic significance for G. repevensis.

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a Faculty of Science, Energy and Environment, King Mongkut?s University of Technology North Bangkok, Rayong Campus, Rayong 21120 Thailand
b Department of Chemistry and Center Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Bangkok 10400 Thailand
c Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400 Thailand
d Division of Chemistry, Faculty of Science and Technology, Rajabhat Rajanagarindra University, Chachoengsao 24000 Thailand
e Department of National Parks, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment, The Forest Herbarium, Bangkok 10900 Thailand

* Corresponding author, E-mail: waraporn.c@sciee.kmutnb.ac.th

Received 31 Aug 2021, Accepted 22 Jan 2022