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Research articles

ScienceAsia 48 (2022):ID 406-413 |doi: 10.2306/scienceasia1513-1874.2022.066

Berberine ameliorates lipopolysaccharide-induced astrocyte activation and migration via NDUFC2

Hua Xu*, Minhao Chen

ABSTRACT:     Astrocytes are an abundant cell type in central nervous system (CNS) and play a critical role in CNS homeostasis. Abnormal astrocytes have been consistently observed in diverse CNS diseases, which lead to enlarged inflammatory reactions and glial scars. As a naturally extracted monomer with anti-inflammatory properties, berberine shows a potential therapeutic effect on abnormal astrocytes. However, the mechanism of berberine in the regulation of abnormal astrocytes is still unclear. Here, we have shown that berberine restored lipopolysaccharide (LPS)-induced mitochondrial abnormalities by upregulating NDUFC2, a subunit of ubiquinone oxidoreductase, expression resulting in astrocyte rehabilitation. Pretreatment of 10 ?g/ml berberine inhibited LPS-induced astrocyte activation and migration. The knockdown of NDUFC2 repressed the inhibitory action of berberine on LPS-induced astrocyte activation and migration; and, as a result, mitochondria injury was increased. These findings prove a new mechanism in astrocyte reaction and provide a potential curative target of berberine for inflammatory diseases.

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a Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong University, Jiangsu 226001 China

* Corresponding author, E-mail: xuhua1981111@126.com

Received 3 Jul 2021, Accepted 9 Feb 2022