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Research articles

ScienceAsia 48 (2022):ID 414-422 |doi: 10.2306/scienceasia1513-1874.2022.070

Reduction of Cd2+ /Ag+ -induced toxicity by 3-mercaptopro-pionic acid-CdSe/ZnS quantum dots and glutathione-CdSe/ ZnS quantum dots in human liver cancer cells

Jian Yina,b,†,*, Jie Zhangb,c,†, Mingli Chena,b, Huancai Yina,b, Jingjing Tiana,b

ABSTRACT:     In the present study, we investigated the interactions between CdSe/ZnS core/shell quantum dots (QDs) and Cd+ 2 and Ag+ in HepG2 cells. Two typical QDs, 3-mercaptopropionic acid-CdSe/ZnS QDs (QD-MPA) and glutathione-CdSe/ZnS QDs (QD-GSH) were applied and proved to be stable, as no fluorescence changes and Cd2+ releasing were detected during 24-h incubation. Both QDs tended to accumulate in HepG2 cells, and significantly reduced the harmful effects of Cd2+ and Ag+ . Correspondingly, the intracellular and extracellular concentrations of free metal ions decreased by 2?5 folds due to their adsorption on QDs. On the other hand, both QDs exhibited no significant adsorption on cell fragments, suggesting that they accumulated inside cells but not on the membrane. Therefore, they did not hinder the uptake of free Cd2+ or Ag+ . After all, the results revealed that highly stable QDs could extensively reduce the toxicity of heavy metals by absorption of heavy metal ions.

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a Department of Bio-Medical Diagnostics, Jinan Guo Ke Medical Technology Development Co., Ltd, Jinan, Shandong 250100 China
b CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, Jiangsu 215163 China
c School of Life Sciences, Shanghai University, Shanghai 200433 China

* Corresponding author, E-mail: yinj@sibet.ac.cn

Received 11 Jun 2021, Accepted 14 Feb 2022