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Research articles

ScienceAsia 47 (2021): 594-601 |doi: 10.2306/scienceasia1513-1874.2021.076

Syntheses of phenylbutanoid and dienone derivatives and their anti-inflammatory activity

Preeyarat Onkuma, Thitinun Karpkirda, Mesayamas Kongsemab, Weerasak Taengphanc, Theerachart Leepaserta,*

ABSTRACT:     A series of phenylbutanoid 4ae and dienone 5ae derivatives were synthesized and characterized by spectroscopic methods. Cytotoxic and anti-inflammatory activities of the synthesized derivatives were investigated at a potentially non-toxic concentration of 15.63 µM (as indicated by cell viability of more than 70%) by measuring the nitric oxide content produced by lipopolysaccharide-stimulated RAW264.7 macrophage cells. Compounds 4b, 4e, 5a, 5b, and 5e at 15.63 µM showed a higher anti-inflammatory activity than the diclofenac drug without affecting cell viability of RAW264.7 macrophage cells. In particular, 5a and 5e showed a nitric oxide inhibition of more than 80%.

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a Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900 Thailand
b Department of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900 Thailand
c Expert Centre of Innovative Herbal Products, Thailand Institute of Scientific and Technological Research, Pathum Thani 12120 Thailand

* Corresponding author, E-mail: fscitcl@ku.ac.th

Received 9 Mar 2021, Accepted 25 Jul 2021