Research articles
ScienceAsia 47 (2021):ID 271-276 |doi:
10.2306/scienceasia1513-1874.2021.024
Marine Streptomyces chumphonensis KK1-2T produces
piericidin A1 as the major secondary metabolite
Wongsakorn Phongsopitanuna,*, Pawina Kanchanasina, Ariya Khanboona,
Pattama Pittayakhajonwutb, Khanit Suwanboriruxc, Somboon Tanasupawata
ABSTRACT: Strain KK1-2T is the type strain of marine Streptomyces chomphonensis. Since the discovery of this
Streptomyces species, the secondary metabolite of the type strain has not been characterized. Based on genome sequence
analysis, the biosynthetic gene cluster of piericidin A1 was detected in the genome of strain KK1-2T. The isolation of
secondary metabolites and spectroscopy data confirm the chemical structure of piericidin A1 produced by the type
strain. This study is the first report of the genome analysis and the secondary metabolite produced by the type strain
of S. chumphonensis.
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| a |
Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences,
Chulalongkorn University, Bangkok 10330 Thailand |
| b |
National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Pathum
Thani 12120 Thailand |
| c |
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences,
Chulalongkorn University, Bangkok 10330 Thailand |
* Corresponding author, E-mail: Wongsakorn.p@chula.ac.th
Received 24 Sep 2020, Accepted 11 Jan 2021
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