ScienceAsia 9 (1983): 047-052 |doi: 10.2306/scienceasia1513-1874.1983.09.047

PHARMACOLOGICAL PROPERTIES OF THE AQUEOUS EXTRACT OF ERYTHROPHLEUM SUCCIRUBRUM GAGNEP LEAVES

JINTANA SATTAYASAI,^a NISON SATTAYASAI,^b PISAMAI LAUPATTARAKASEM,^a VEERAPOL KUKONGVIRIYAPAN,^a THONGDANG THAWANLA,^b PRONROONG LOUCHAISA,^b VIWAT HAHNVAJANAWONG^b and PRANOM CHANTARANOTHAI^c

ABSTRACT: The aqueous extract of Erythrophleum succirubrum Gagnep leaves given to mice by intraperitoneal route was shown to cause poisoning. The LS₅₀ of the extract in mkt! was 20 g/kg body weight. The extract given to anesthetized rats, O.5 g/kg body weight intravenously produced a significant increase in blood pressure. In isolated preparations. the extract stimulated rat ileum. rat atria and rat phrenic nerve-hemidiaphragm. The stimulation in rat atria and phrenic nerve-hemidiaphragm was followed by inhibition.

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a Department of Pharmacology, Faculty of Medicine, Khon Kaen University,
b Department of Chemistry, Faculty of Science, Khon Kaen University, and
c Department of Biology, Faculty of Science. Khon Kaen University, Thailand

Received 13 December 1982