Research articles
ScienceAsia 51 (2023): 1-9 |doi:
10.2306/scienceasia1513-1874.2023.053
Thermal degradation kinetics of phenylbutanoids in Zingiber
montanum extract and stability improvement by oil extraction
Vanuchawan Wisuitiprota, Wuttichai Jaideeb, Kanita Pheangsaludc, Apichart Ngernsoungnerne,
Piyada Ngernsoungnerne, Chompunoot Wangboone, Naruwan Saowakone, Pishyaporn Sritangose,
Wudtichai Wisuitiprotc,d,*
ABSTRACT: (E)-1-(3,4-dimethoxyphenyl) butadiene (DMPBD) and (E)-4-(3?,4?-dimethoxyphenyl)-but-3-en-1-ol
(Compound D), both phenylbutanoids, are recognized as potent anti-inflammatory agents predominantly found in
the essential oil or rhizome extract of Zingiber montanum. The instability of phenylbutanoids plays a pivotal role in
determining the efficacy of formulations containing extracts or essential oils derived from Z. montanum rhizomes. This
current study aimedtodemonstratetheimpactoftemperatureontheCompoundDandDMPBDpresentinZ.montanum
extract (ZME) and Z. montanum oil (ZMO) obtained by hot oil extraction. The stability of Compound D and DMPBD
is assessed by investigating thermal degradation kinetics and predicting shelf life using Arrhenius plot models. The
f
indings unveiled that Compound D and DMPBD exhibit degradation following a first-order kinetic model. Under this
model, the predicted shelf life of ZME at 25?C for Compound D and DMPBD amounts to 12.14 days and 10.18 days,
respectively. In contrast, the anticipated shelf life of these compounds in ZMO extends to 480.31 days and 188.57 days,
respectively. Consequently, Compound D and DMPBD within ZMO hold significant promise for further advancement in
product development.
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| a |
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200 Thailand |
| b |
Medicinal Plants Innovation Center of Mae Fah Luang University, Chiang Rai 57100 Thailand |
| c |
Sirindhorn College of Public Health Phitsanulok, Faculty of Public Health and Allied Health Sciences,
Praboromarajchanok Institute, Ministry of Public Health, Phitsanulok 65130 Thailand |
| d |
Herbal and Research Unit, Faculty of Public Health and Allied Health Sciences, Praboromarajchanok Institute,
Ministry of Public Health, Phitsanulok 65130 Thailand |
| e |
School of Preclinical Sciences, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000
Thailand |
* Corresponding author, E-mail: wudtichai@scphpl.ac.th
Received 12 Dec 2023, Accepted 0 0000
|
