Research articles
ScienceAsia 51 (2023): 1-10 |doi:
10.2306/scienceasia1513-1874.2023.063
Aphrodisiac potential of Derris scandens (Roxb.) Benth. stem
extract on mating behaviors in immobilization-induced stress
male rats
Nattiya Chaichamnonga,b, Pornnarin Taepavaraprukc,d,*, Prapapan Temkittawona,
Kornkanok Ingkaninana,*
ABSTRACT: This study aimed to investigate the aphrodisiac potential effects of Derris scandens (Roxb.) Benth. stem
extract (DE) on the mating behaviors in immobilization-induced stress male rats. Forty-eight male Wistar rats were
divided into 6 groups: Normal control, Stressed control, Stressed rats that received DE 200, 400, and 800 mg/kg/day
for 14 days, and Stressed rats that received sildenafil citrate 5 mg/kg/day. The rats were exposed to immobilization
for 6 h per day for 14 days to induce stress. Mating behaviors were studied on Day 0 and Day 14. On Day 15, blood
was collected by heart puncture for testosterone and cortisol level evaluation, and sperm was collected from both
sides of the caudal epididymis and vas deferens. Neurotransmitter levels extracted from the brain were measured by
HPLC-ECD analysis. Superoxide dismutase (SOD) was evaluated using SOD Assay Kit. The results showed that the
administration of DE significantly motivated the mating behaviors by reducing the mount latency and intromission
latency and increasing the intromission number. The increases in sperm count and SOD activity were only observed
in the stressed rats treated with DE 400 mg/kg. The stressed rats that received 800 mg/kg of DE showed a significant
increase in dopamine levels and a decrease in norepinephrine levels. Our studies provide experimental evidence that
400 and 800 mg/kg DE can be effective in improving male rat sexual performance.
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| a |
Center of Excellence in Cannabis Research, Department of Pharmaceutical Chemistry and Pharmacognosy,
Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University,
Phitsanulok 65000 Thailand |
| b |
Division of Applied Thai Traditional Medicine, Faculty of Public Health, Naresuan University,
Phitsanulok 65000 Thailand |
| c |
Department of Physiology, Faculty of Medical Sciences, Naresuan University, Phitsanulok 65000 Thailand |
| d |
Center for Animal Research, Naresuan University, Phitsanulok 65000 Thailand |
* Corresponding author, E-mail: taepavap@yahoo.com, k_ingkaninan@yahoo.com
Received 5 Oct 2023, Accepted 0 0000
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