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Volume 43 Number 4 Volume 43 Number 5 Volume 43 Number 6

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Research articles

ScienceAsia 43 (2017): 275-280 |doi: 10.2306/scienceasia1513-1874.2017.43.275

Antibacterial activity of essential oil from Wedelia trilobata leaves against Propionibacterium granulosum

Nuttakorn Baisaenga,*, Rungthip Kawareeb, Anthika Boonmaa, Jariya Sadnena, Sunisa Khamkaewa, Srikanjana Klayraungb

ABSTRACT:     This study reports on the in vitro antibacterial activity of hydro-distilled essential oil from Wedelia trilobata (L.) Hitchc leaves against Propionibacterium granulosum. The percentage yield of this essential oil via hydrodistillation was 0.21±0.01% (v/w). A total of 112 chemical components present in the essential oil from W. trilobata leaves representing 62% of the total oil were identified by gas chromatography-mass spectrometry. The main bioactive constituents were monoterpenes, α-pinene (19.5%), α-phellandrene (7.4%), limonene (3.6%), oxazine (3.3%), and β-pinene (3.1%). This essential oil showed the moderate antioxidant capacity of 1,1-diphenyl-2-picrylhydrazyl (DPPH) compared to the trolox equivalent antioxidant capacity and gallic acid equivalent, and possessed anti-P. granulosum activity from the inhibition zone from the disc diffusion method. The minimum inhibitory concentration (MIC, 595±206 µg/ml) and minimum bacterial concentration (MBC, 1191±413 µg/ml) values of this essential oil were higher than the MIC (1.30±0.37 µg/ml) and MBC (2.61±0.91 µg/ml) values of commercial clindamycin gel and the MIC (52±18 µg/ml) and MBC (104±36 µg/ml) values of commercial benzoyl peroxide gel. The results provide new information on the hydro-distilled essential oil from W. trilobata leaves, which may be important for developing new alternative anti-acne products.

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a School of Pharmaceutical Sciences, University of Phayao, Phayao 56000 Thailand
b Division of Biotechnology, Faculty of Science, Maejo University, Chiang Mai 50290 Thailand

* Corresponding author, E-mail: patchateeya@yahoo.com

Received 28 Jun 2017, Accepted 6 Nov 2017