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Research articles

ScienceAsia 43 (2017): 223-228 |doi: 10.2306/scienceasia1513-1874.2017.43.223

Antifungal activities of essential oils of Syzygium aromaticum, Piper betle, and Ocimum sanctum against clinical isolates of canine dermatophytes

Jareerat Aiemsaard, Korawuth Punareewattana*

ABSTRACT:     Current antifungal drugs for canine dermatophytosis are effective but may cause adverse effects or drug resistance. In this study, three essential oils from Syzygium aromaticum (L.) Merr. & Perry, Piper betle, and Ocimum sanctum were investigated for their antifungal activities. Fungal organisms were standard strains and clinical isolates of Trichophyton mentagrophytes, Microsporum canis, and Microsporum gypseum. Minimum inhibition concentration (MIC) and minimum fungicidal concentration (MFC) were evaluated. The composition of the essential oils was determined by GC/MS analysis. MIC and MFC tests indicated that the antifungal activities of these three essential oils were high (MIC range 0.2–1.6 µl/ml) and fungal samples from both sources had similar sensitivity to antifungal drug and essential oils. The results of essential oil analysis revealed that eugenol and its derivatives were the major components possessing antifungal activity. In conclusion, this study demonstrated the potential of all three essential oils as highly effective antifungal agents against canine dermatophytes.

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Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002 Thailand

* Corresponding author, E-mail: korawut@kku.ac.th

Received 22 Dec 2016, Accepted 24 Sep 2017