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Research articles

ScienceAsia 41(2015): 392-399 |doi: 10.2306/scienceasia1513-1874.2015.41.392


Anti-inflammatory activity of a Vernonia˙cinerea methanolic extract in vitro


Aurasorn˙Saraphanchotiwitthayaa,b,*, Pattana˙Sripalakitb,c

 
ABSTRACT:     Vernonia cinerea Less. (Asteraceae) is a herbaceous plant commonly found in SE Asia. Different parts of V.˙cinerea have been used in various folklore medicine applications, including reducing inflammation and detoxification. This study investigates the effects of V.˙cinerea methanolic extract on the mouse immune system in vitro. Cytokine detection of ConA-stimulated splenocytes using ELISA, mitogen-induced splenocyte proliferation, and phagocytic activity were assayed. The results show that the extract shifted the Th1/Th2 balance towards a Th2 type response. Additionally, Th1- and Th2-related cytokine production correlated with lymphocyte proliferation by selective activation of T-cells into Th2-cells and suppression of Th1-cell proliferation. Our results confirmed the traditional applications of V.˙cinerea on immune-related remedies and anti-inflammation, suggesting a potential therapeutic application of this plant in the treatment of diseases associated with Th1-related cytokine production and inflammation.

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a Department˙of˙Pharmaceutical˙Technology, Faculty˙of˙Pharmaceutical˙Sciences, Naresuan˙University, Phitsanulok, Thailand
b Pharmaceutical˙Biotechnology˙Research˙Unit, Faculty˙of˙Pharmaceutical˙Sciences, Naresuan˙University, Phitsanulok, Thailand
c Department˙of˙Pharmaceutical˙Chemistry˙and˙Pharmacognosy, Faculty˙of˙Pharmaceutical˙Sciences, Naresuan˙University, Phitsanulok, Thailand

* Corresponding author, E-mail: aurasorns@nu.ac.th

Received 6 Aug 2014, Accepted 2 Nov 2015