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Research articles

ScienceAsia 41(2015): 236-245 |doi: 10.2306/scienceasia1513-1874.2015.41.236


Stability and clinical effectiveness of emulsion containing Asparagus˙racemosus root extract


Tammanoon˙Rungsanga, Punpimol˙Tuntijarukornb, Kornkanok˙Ingkaninanc, Jarupa˙Viyocha,*

 
ABSTRACT:     Asparagus racemosus root extract was entrapped in hydroxypropyl-β-cyclodextrin (HPβCD) by a physical mixing method and then incorporated in an oil in water (o/w) emulsion to evaluate its stability and clinical effectiveness. After the emulsion containing the HPβCD-entrapped extract was kept at 45.0±2.0˙°C for 90˙days, 90% of saponins, major compounds of the extract, remained. Without entrapment with HPβCD, the amount of saponins would have decreased to 10% after storage for 60˙days. After application of the emulsion containing the entrapped extract or the unentrapped extract to the outermost layer of full thickness skin, about 38% of saponins could penetrate into the skin. A higher amount of saponins was accumulated in the outermost layer applied with emulsion containing the entrapped extract. For a clinical study, measurement of the surface evaluation of wrinkles (SEw) at the zygomatic area of the face was measured at weeks 8 and 12. The average SEw value of group of subjects that applied the extract-free emulsion was significantly higher than that of the group that applied the emulsion containing the entrapped extract (p<0.05). Our study indicates that in o/w emulsion, saponins in A.˙racemosus root extract could maintain their stability after entrapping the extract within HPβCD. Moreover, the effectiveness of the entrapped extract on prevention of wrinkle progression was seen.

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a Department˙of˙Pharmaceutical˙Technology, Faculty˙of˙Pharmaceutical˙Sciences˙and Centre˙of˙Excellence˙for˙Innovation˙in˙Chemistry, Naresuan˙University, Phitsanulok˙65000˙Thailand
b Cosmetics˙and˙Natural˙Products˙Research˙Centre, Faculty˙of˙Pharmaceutical˙Sciences˙and Centre˙of˙Excellence˙for˙Innovation˙in˙Chemistry, Naresuan˙University, Phitsanulok˙65000˙Thailand
c Department˙of˙Pharmaceutical˙Chemistry˙and˙Pharmacognosy, Faculty˙of˙Pharmaceutical˙Sciences˙and Centre˙of˙Excellence˙for˙Innovation˙in˙Chemistry, Naresuan˙University, Phitsanulok˙65000˙Thailand

* Corresponding author, E-mail: jarupav@nu.ac.th

Received 10 Jun 2014, Accepted 24 Aug 2015