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Research articles

ScienceAsia 40(2014): 141-144 |doi: 10.2306/scienceasia1513-1874.2014.40.141

Detection and confirmation of hispolon in the mushroom Phellinus linteus

Padungrat Toopmuanga, Chutarat Khamchuma,b, Vittaya Punsuvona,b,c,*

ABSTRACT:     Phellinus linteus (PL), a mushroom known as krathin phiman in Thai, has been used as a traditional medicine in the treatment of various cancers. Hispolon obtained from PL ethanol extracts is a promising anti-cancer compound. In this study, ethanol concentration and extraction time were varied for a soxhlet extraction. The content of hispolon in a crude extract was determined by high performance liquid chromatography with a UV detector. The presence of hispolon in the crude extract was demonstrated by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with daughter ion scanned mode. The results showed that both hispolon and Thai PL have a similar parent ion at m/z 218.91 and daughter ions at m/z 176, 160, 135.

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a Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900 Thailand
b Centre of Excellent-Oil Palm, Kasetsart University, Bangkok 10900 Thailand
c Centre of Advanced Studied in Tropical Natural Resource, NRU-KU, Kasetsart University, Bangkok 10900 Thailand

* Corresponding author, E-mail: fscivit@ku.ac.th

Received 6 Aug 2013, Accepted 7 Jan 2014