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Research articles

ScienceAsia 40(2014): 212-218 |doi: 10.2306/scienceasia1513-1874.2014.40.212


Association of adenosine triphosphate-binding cassette transporter A1 gene polymorphism with lipid profiles and early-onset type 2 diabetes


Chieh-Hsiang Lua,b,c, Wen-Ling Liaod,e, Tzu-Yuan Wangf, Ching-Chu Chenf, Yung-Hsiang Chene,g, Siu-San Tseh, Yu-Chuen Huangi,j, Fuu-Jen Tsaii,j,k,l,*

 
ABSTRACT:     Adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays an important role in lipid metabolism and is involved in diabetes. We investigated the associations between lipid profiles and an early-onset diabetic phenotype with ABCA1 genotypes among 999 type 2 diabetes mellitus patients in the Han Chinese population of Taiwan. During study enrolment, blood samples were collected by venipuncture from these patients for genomic DNA isolation and serological tests, and data related to the diabetes age of onset were collected using a self-report questionnaire. Four single-nucleotide polymorphisms (SNPs) were selected for genotyping by polymerase chain reaction in each patient. The present study found that the high-density lipoprotein (HDL) levels were significantly different among patients with different genotypes at SNP rs2487039 (p=0.018). The body mass index (BMI) was also significantly different among patients with different genotypes at SNP rs2487039, rs2230806, and rs200069 (p=0.009, 0.004, and 0.003, respectively). The polymorphisms at position rs10121901 in ABCA1 were statistically associated with development of early-onset type 2 diabetes mellitus (p=0.013), with an odds ratio of 0.78 (95% confidence interval: 0.64–0.95). In conclusion, an ABCA1 variant is associated with HDL level, BMI, and early-onset type 2 diabetes mellitus in a specific Taiwanese population.

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a Division of Endocrinology and Metabolism of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan
b Department of Business Administration, National Chung Cheng University, Chia-yi County, Taiwan
c TaTung Institute of Commerce and Technology, Chia-yi City, Taiwan
d Centre for Personalized Medicine, China Medical University Hospital, Taichung, Taiwan
e Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan
f Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung, Taiwan
g Graduate Institute of Acupuncture Science, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan
h Department of Surgery, Division of Urology, Tung's Taichung Metroharbor hospital
i College of Chinese Medicine, China Medical University, Taichung, Taiwan
j Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung, Taiwan
k Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan
l Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan

* Corresponding author, E-mail: d0704@www.cmuh.org.tw

Received 4 Jul 2013, Accepted 6 Mar 2014