| Home  | About ScienceAsia  | Publication charge  | Advertise with us  | Subscription for printed version  | Contact us  
Editorial Board
Journal Policy
Instructions for Authors
Online submission
Author Login
Reviewer Login
Volume 48 Number 6
Volume 48 Number 5
Volume 48 Number 4
Volume 48 Number 3
Volume 48 Number 2
Volume 48S Number 1
Earlier issues
Volume 39 Number 5 Volume 39 Number 6 Volume 40S Number 1

previous article next article

Research articles

ScienceAsia 39 (2013): 605-609 |doi: 10.2306/scienceasia1513-1874.2013.39.605

In vitro antioxidant and antidiabetic activities of Rehmannia glutinosa tuberous root extracts

Hyun Ju Jeonga, Ju-Sung Kimb, Tae Kyung Hyunc, Jinfeng Yanga, Hak-Hee Kangd, Jun-Cheol Chod, Hun-Myeong Yeomd, Myong Jo Kima,*

ABSTRACT:     To analyse the antioxidant and antidiabetic activities of Rehmannia glutinosa tuberous roots, extracts with nine different solvents were investigated. Antioxidant activity was measured with two methods, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and reducing power. Each extract exhibited a dose-dependent free radical scavenging action against DPPH and a reducing power, but diverse antioxidant activities. To determine the anti-diabetic activity, we measured the α-glucosidase inhibitory capacity of each extract. We found that 10 µg/ml of 60% MeOH or 80% of MeOH extract inhibited more than 90% of α-glucosidase activity, and this inhibitory activity was not mediated by catalpol, a major iridoid constituent of R. glutinosa tuberous roots. Overall, the data suggested that the tuberous roots of R. glutinosa have potential as natural antioxidants and antidiabetics.

Download PDF

33 Downloads 1121 Views

a Department of Applied Plant Sciences, Kangwon National University, 200-701, Chuncheon, Republic of Korea
b College of Applied Life Sciences, the Research Institute for Subtropical Agriculture and Biotechnology, Jeju National University, Jeju 690-756, Republic of Korea
c Department of Biochemistry, Gyeongsang National University, Jinju 660-701, Republic of Korea
d Skin Research Institute, AmorePacific Corporation R&D Centre, Yongin, Gyeounggi-do, 446-729, Republic of Korea

* Corresponding author, E-mail: kimmjo@kangwon.ac.kr

Received 15 Apr 2013, Accepted 19 Oct 2013