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Research articles

ScienceAsia 39(2013): 605-609 |doi: 10.2306/scienceasia1513-1874.2013.39.605

In vitro antioxidant and antidiabetic activities of Rehmannia glutinosa tuberous root extracts

Hyun Ju Jeonga, Ju-Sung Kimb, Tae Kyung Hyunc, Jinfeng Yanga, Hak-Hee Kangd, Jun-Cheol Chod, Hun-Myeong Yeomd, Myong Jo Kima,*

ABSTRACT:     To analyse the antioxidant and antidiabetic activities of Rehmannia glutinosa tuberous roots, extracts with nine different solvents were investigated. Antioxidant activity was measured with two methods, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and reducing power. Each extract exhibited a dose-dependent free radical scavenging action against DPPH and a reducing power, but diverse antioxidant activities. To determine the anti-diabetic activity, we measured the α-glucosidase inhibitory capacity of each extract. We found that 10 µg/ml of 60% MeOH or 80% of MeOH extract inhibited more than 90% of α-glucosidase activity, and this inhibitory activity was not mediated by catalpol, a major iridoid constituent of R. glutinosa tuberous roots. Overall, the data suggested that the tuberous roots of R. glutinosa have potential as natural antioxidants and antidiabetics.

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a Department of Applied Plant Sciences, Kangwon National University, 200-701, Chuncheon, Republic of Korea
b College of Applied Life Sciences, the Research Institute for Subtropical Agriculture and Biotechnology, Jeju National University, Jeju 690-756, Republic of Korea
c Department of Biochemistry, Gyeongsang National University, Jinju 660-701, Republic of Korea
d Skin Research Institute, AmorePacific Corporation R&D Centre, Yongin, Gyeounggi-do, 446-729, Republic of Korea

* Corresponding author, E-mail: kimmjo@kangwon.ac.kr

Received 15 Apr 2013, Accepted 19 Oct 2013