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Volume 40S Number 1 Volume 40 Number 1 Volume 40 Number 2

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Research articles

ScienceAsia 40(2014): 42-47 |doi: 10.2306/scienceasia1513-1874.2014.40.042

Negative effects of Aloe vera gel on paracetamol-induced liver injury in rats

Suchittra Samuhasaneetoa,*, Sorrayut Kajornvuthidejb

ABSTRACT:     The effect of Aloe vera gel on paracetamol induced liver injury in rats was studied using male Wistar rats divided into four groups. Group 1 (control) received 50% sucrose orally twice daily for 2 days. Group 2 (paracetamol) received a single dose (2.5 g/kg BW) of paracetamol dissolved in 50% sucrose. Groups 3 and 4 (A. vera 100 mg and 300 mg, respectively) received a single dose (2.5 g/kg BW) of paracetamol dissolved in 50% sucrose followed by 100 or 300 mg/kg BW of A. vera gel twice daily for 2 days. Blood was collected to determine alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymatic activities. Liver tissue samples were collected for hepatic glutathione, hepatic malondialdehyde (MDA), and histopathology. The results showed that the serum levels of ALT, AST, and hepatic MDA increased significantly in the paracetamol group compared to that of the control group. The liver histopathology in the paracetamol group revealed vacuolization, cell swelling, and mild infiltration of inflammatory cells around the central vein. Necrosis was observed predominantly around the centrilobular and midzonal regions. There were no differences in hepatic glutathione levels between groups and no difference in hepatic MDA levels between the paracetamol group and A. vera gel treated groups. This study concluded that neither 100 nor 300 mg/kg BW of A. vera protected rats from the liver damage induced by a high dose of paracetamol.

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a School of Medicine, Walailak University, Nakhon Si Thammarat 80161 Thailand
b Institute of Pathology, Department of Medical Services, Ministry of Public Health, Bangkok 10400 Thailand

* Corresponding author, E-mail: ssuchitt@wu.ac.th

Received 26 Feb 2013, Accepted 22 Dec 2013