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ScienceAsia 39(2013): 94-98 |doi: 10.2306/scienceasia1513-1874.2013.39.094


Antimalarial activity and cytotoxicity of zerumbone derivatives


Uraiwan Sriphanaa, Siripit Pitchuanchoma, Palangpon Kongsaereeb, Chavi Yenjaia,*

 
ABSTRACT:     Zerumbone, a sesquiterpene isolated from the rhizome of Zingiber zerumbet, shows strong antimalarial and cytotoxic activities. A series of zerumbone derivatives were synthesized and evaluated for in vitro antimalarial activity against Plasmodium falciparum and cytotoxicity against human cancer cell lines (NCI-H187, KB and BC) as well as normal cells (Vero cells). Three of the compounds showed potent antimalarial activity with IC50 values of 32.8, 13.7, and 9.8 µM. They were less toxic against Vero cells.

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a Natural Products Research Unit, Department of Chemistry and Centre of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Khaen 40002 Thailand
b Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400 Thailand

* Corresponding author, E-mail: chayen@kku.ac.th

Received 17 Jul 2012, Accepted 27 Dec 2012