ZIF-8, chitosan and β-cyclodextrin-incorporated ZIF-8 nanohybrid for improving drug delivery

Weenawan Somphon*, Arthorn Loisruangsin

ABSTRACT: The success of encapsulation of two model drugs, anti-Alzheimer donepezil (DH) and antibiotic nitrofurantoin (NF), in ZIF-8 through the one-pot method was reported here. The one-pot method was further applied to incorporate chitosan (CS) or ?-cyclodextrin (BCD) into the encapsulation of the drug in ZIF-8. The characterization of the samples was carried out experimentally via UV-vis spectroscopy, FT-IR, XRD, SEM, TEM, TGA, and zeta potential analysis; and computationally via molecular docking and geometric optimization calculations. The drug loadings and drug releases of the samples were then explained. The binding interaction of the model drugs on other components and morphology and molecular weight of the coating material affects both the drug loading and drug release. DH mainly contributed in the interior and on the surface of ZIF-8. Free voids of the coating CS were assumed to play the role of NF loading since the binding of NF to the surface of ZIF-8 was limited by the N-Zn coordinate bond. Physical properties of coating materials such as viscosity and solubility were considered for explaining different drugs at a neutral pH, while the protonation of the amine group of DH or CS became predominant for the drug release at an acidic pH.

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^a	Division of Chemistry, Department of Physical and Material Sciences, Faculty of Liberal Arts and Science, Kasetsart University Kamphaeng Saen Campus, Nakhon Pathom 73140 Thailand

* Corresponding author, E-mail: weenawan.s@ku.th

Received 18 Jun 2022, Accepted 4 Aug 2023