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Research articles

ScienceAsia 48 (2022): 488-490 |doi: 10.2306/scienceasia1513-1874.2022.060


N-methylcantharidimide: Synthesis and purification


Chun Bin Tan*, Xing Fang Qiao, Xiao Ling Liu, Ben Zhong Mi, Ji Chun Ran*

 
ABSTRACT:     N-methylcantharidimide (NMC), a derivative of cantharidin (C), shows antitumor properties. In this study, NMC was synthesized from C and methylamine with a yield of over 90%. We investigated the influences of different amounts of methylamine used in this reaction, and found that the optimal methylamine dosage was twice the theoretical amount. Furthermore, in the purification of NMC, distilled water was the most suitable solvent. This improved method is both simple and economical, and this process could be further developed at an industrial scale for the synthesis of NMC.

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a Chongqing Academy of Chinese Materia Mediea, Chongqing 400065 China

* Corresponding author, E-mail: tcb204@163.com, 515204279@qq.com

Received 28 Jul 2021, Accepted 24 Jan 2022