ScienceAsia 9 (1983): 081-088 |doi: 10.2306/scienceasia1513-1874.1983.09.081
3-0-ANGELOYLINGENOL, THE TOXIC AND SKIN IRRITANT FACTOR FROM LATEX OF EUPHORBIA ANITIQUORUM L. (EUPHORBIACEAE) AND FROM A DERIVED THAI PURGATIVE AND ANTHELIMINTIC (VERMIFUGE) DRUG
W. ADOLF,a S. CHANAIb and E. HECKERa
ABSTRACT: From latex of Euphorbia antiquorum L. as well as from the purgative and anthelmintic (vermifuge) Thai drug yang Sa-Lad-Dai (dried, powdered latex) the highly skin irritant and toxic Euphorbia factor An1 was isolated by combination of countercurrent distributions and chromatography. Spectroscopic and chemical characterisation of An1 established its structure as 3-O-angeloylingenol (I). Because of the acute toxicity of factor An1 and of the possible risk of co-carcinogenesis by tumor promotion. Utilization of drugs made up from dried or fresh latex as practiced in Thailand in purgath'es and vermifuges should be abandoned.
a. Deutsches Krebsforschungszentrum, Institut fur Biochemie, Im Neuenheimer Feld
280, D-6900 Heidelberg, FRG
b. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University,
Received 29 March 1983