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Research Article

ScienceAsia 3 (1977): 027-033 |doi: 10.2306/scienceasia1513-1874.1977.03.027

 

SUCCINYLATED GLUCAGON: PREPARATION, SOME PHYSICAL PROPERTIES AND HORMONAL ACTION

 

B. PANIJPAN and P. YAMARAT

Summary: A succinylated derivative of glucagon has been prepared and its purity is established. It is much more soluble than glucagon at neutral pH and has a pI of about 3.3. Proton magnetic resonance studies clearly show its existence as a random coil. Its adenyl cyclase stimulatory activity is about 40-50% of that of glucagon.

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Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, Thailand

Received 31 January 1977