| Home  | About ScienceAsia  | Publication charge  | Advertise with us  | Subscription for printed version  | Contact us  
Editorial Board
Journal Policy
Instructions for Authors
Online submission
Author Login
Reviewer Login
Volume 50 Number 1
Volume 49 Number 6
Volume 49 Number 5
Volume 49S Number 1
Volume 49 Number 4
Volume 49 Number 3
Earlier issues
Volume  Number 

previous article next article

Research articles

ScienceAsia 47 (2021): 549-555 |doi: 10.2306/scienceasia1513-1874.2021.068


Evaluation of anti-inflammatory, cytotoxic, anti-H. pylori, antioxidant activities, and phytochemical compositions of Shirakiopsis indica (Willd.) Esser


Khwanchanok Mokmueda, Bhanuz Dechayontb, Pathompong Phuakleeb, Chantubpapa Liplungb, Harit Muangpoolsawadb, Nitra Nuengchamnongc, Nuntika Prommeea,*

 
ABSTRACT:     Shirakiopsis indica (Willd.) Esser (Sa-Mor-Ta-Lay, in Thai), a herbal plant belonging to the family Euphorbiaceae, has traditionally been used to treat gastrointestinal symptoms. The objectives of this study were to investigate the bioactivities (cytotoxic, antioxidant, anti-inflammatory, and anti-Helicobacter pylori) of S. indica extracts that influence the treatment of gastric inflammation. The chemical constituents of the extracts were also analyzed by performing LC-ESI-QTOF-MS/MS; and they are tentatively identified as Sapintoxin A, Sapintoxin B, Sapintoxin C, Saipinin, and a few other phorbol esters. We found that the ethanolic extract of S. indica exhibited the highest cytotoxicity against the Kato III gastric cancer cell line and the highest inhibition of nitric oxide production with the IC50 values of 3.21 ± 0.77 and 12.99 ± 2.42 µg/ml, respectively. The water extract of S. indica exhibited higher anti-H. pylori activity than that of the ethanolic extract, and exhibited strong antioxidant activity on DPPH and ABTS.+ assay with the IC50 values of 8.169 ± 0.65 and 20.03 ± 1.33 µg/ml, respectively. Our results give new science-based evidence that S. indica fruit extract has a potential for treatment of gastritis. Pharmacological activities and toxicity in animal models should be further investigated.

Download PDF

196 Downloads 909 Views


a Division of Applied Thai Traditional Medicine, Faculty of Public Health, Naresuan University, Phitsanulok 65000 Thailand
b Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120 Thailand
c Science Laboratory Centre, Faculty of Science, Naresuan University, Phitsanulok 65000 Thailand

* Corresponding author, E-mail: nuntikap@nu.ac.th

Received 10 Jan 2021, Accepted 4 Jun 2021