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Research articles

ScienceAsia 46 (2020): 457-461 |doi: 10.2306/scienceasia1513-1874.2020.059

Size-controlled chitosan nanoparticles prepared using ionotropic gelation

Setia Budia,*, B. Asih Suliasihb, Indah Rahmawatia, Erdawatia

ABSTRACT:     This work aimed at controlling the size of chitosan nanoparticles that were prepared by the ionotropic gelation method. Quantities of chitosan and sodium tripolyphosphate (STPP) were optimized to obtain a fine size and narrow size distribution of the nanoparticles. X-ray diffraction and selected area electron diffraction patterns indicated the existence of both crystalline and amorphous phases of chitosan. Particle size and size distribution were determined using transmission electron microscopy and dynamic laser scattering techniques. The size of the chitosan particles decreased with a reduction in STPP content due to a decrease in cross-link bonding and the formation of aggregate particles. Using this facile approach, the finest particles of chitosan were obtained in a range of 3?6 nm.

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a Department of Chemistry, Faculty of Mathematics and Science, Universitas Negeri Jakarta, Jakarta Timur 13220 Indonesia
b Faculty of Pharmacy, Universitas Indonesia, Depok 16424 Indonesia

* Corresponding author, E-mail: setiabudi@unj.ac.id

Received 9 Jul 2019, Accepted 25 Jul 2020